As a test subject in the same Weapon X program that had previously given Wolverine his adamantium claws and skeleton, Wade Wilson received a healing factor that prevented his cancer from killing him.Marvel Source
Wade soon escaped the program and became a freelance mercenary using the name Deadpool, working for various criminal organizations. At times he has teamed up with heroes as well, but these attempts at "being a good guy" rarely stick for long.
Wade is mentally unstable, though whether this is a normal state or is caused by his constant state of hyper-regeneration is unknown. One side effect of his mental state is the belief that he is not a real person but actually a character in a comic book.
Deadpool Unlished
This build focus on DOTs and melee.
Your attack cycle ll be :
1. to reach your target with a 5sec damage & move speed buff.
2. to place your 1st DOT & weaken enemies (+10% dam).
3. to place your 2nd DOT.
4. to deal massive damages until DOTs have expired.
5. to drop buffing & healing dolls for you and your teamates.
Medallion :
[item]33[/item] for the shared DPS buff and potential invulnerability.
Relic :
[item]213[/item] or [item]185[/item] for damage oriented specs and [item]187[/item] for more survivability.
Artifacts :
[item]101[/item] for the health & spirit on dodge.
[item]234[/item] for the DPS and skills boost.
[item]103[/item] for the overall DPS boost.
[item]221[/item] for the DPS and survivability boost.
Uru-Forged :
Uru-Forged War Gauntlets for the physical damage boost is a good choice.
Runewords :
Bone Breaker is a good choice for damage oriented builds with +1 STR, 200 damage rating on melee attacks, +2% ATK speed & 2% ATK and move speed debuff on melee hit.
River of Souls is a good choice if you re still in need of spirit regeneration to keep using skills without cooldown.
Enchants :
Either Cattle for the health boost and more survivability or Serpent for the dodge boost and more chance to regen spirit combined with [item]101[/item].
Blessings :
Hela on all items to get a massive boost in brutal strike chances.
Legendary :
Gungir is the best damage oriented legendary for Deadpool (R1 +400 critical rating, R2 +1000 critical damage, R3 +400 critical rating, R4 +1000 critical damage and R5 5% chance on hit to get +1000 brutal strike rating for 5sec).
My other builds
Ghost Rider Unlished
Hulk Unleashed
Gambit Unleashed