As a test subject in the same Weapon X program that had previously given Wolverine his adamantium claws and skeleton, Wade Wilson received a healing factor that prevented his cancer from killing him.Marvel Source
Wade soon escaped the program and became a freelance mercenary using the name Deadpool, working for various criminal organizations. At times he has teamed up with heroes as well, but these attempts at "being a good guy" rarely stick for long.
Wade is mentally unstable, though whether this is a normal state or is caused by his constant state of hyper-regeneration is unknown. One side effect of his mental state is the belief that he is not a real person but actually a character in a comic book.
BLEED STAB REPEAT
But seriously. Fast paced build focusing Melee, Bleeds, and Crit.
Foot Gougers is the most used ability here as it's constant damage and the only real AoE damage this build has. The slow and attack speed debuff is very helpful as well.
Single target DPS is where this build really shines. Lay down Foot Gougers, apply bleeds with Flesh Wound and Slice & Dice, then Big Ol' Stab for a stun and 50% extra damage to bleeding targets. Continue this rotation and watch the health bars melt.
Deadpool is a little squishier than he used to be, so pumping points into his defensive passives (Safety Through Stabbing & Superior Healing Factor) makes life as a psychopathic mercenary a little easier.
Bang Boom I use as a ranged cleanup for straggling minions and when I can't get in close to a boss. I've been tossing between this and the other basic ranged abilities, but having the extra AoE on Bang Boom is what led me to keep this one instead.
(Guide work in progress)