As a test subject in the same Weapon X program that had previously given Wolverine his adamantium claws and skeleton, Wade Wilson received a healing factor that prevented his cancer from killing him.Marvel Source
Wade soon escaped the program and became a freelance mercenary using the name Deadpool, working for various criminal organizations. At times he has teamed up with heroes as well, but these attempts at "being a good guy" rarely stick for long.
Wade is mentally unstable, though whether this is a normal state or is caused by his constant state of hyper-regeneration is unknown. One side effect of his mental state is the belief that he is not a real person but actually a character in a comic book.
Game Play:
After played this for few days I found that max out Power Ups are a lot more useful than Get Better Faster. Deadpool Melee build really doesn't have much buttons to smash, I use bodyslide to get out some of the tough situitation, and drop Foot Gougers while stationary.
Core:
Recent patches introduced Adamantium Core with 3 stats, try to find one with + Strength, + Fighting Skill and 25% Drop Rarity Boost. I was lucky and I found one while cruising through mid town.
Artifacts:
Edge of Infinity + Pym Shrinking Serum (Combo)
Vita-Ray Projector + Fearsome Fist of Farallah (Combo)
Side note: I really don't recommend Edge of Infinity + Pym Shrinking Serum combo if you don't have a lot of crit, especially for leveling player, you can pretty much use Vita-Ray Projector + Fearsome Fist of Farallah combo till you stack up to at least 25% crit.
Medals:
Juggernaut Medallion
Elektra Medallion
or
Lady Deathstrike Medallion
Bullseye Medallion
or
Doctor Doom Medallion (This medallion is good for + damage and + duration)
Happy hunting.