As a test subject in the same Weapon X program that had previously given Wolverine his adamantium claws and skeleton, Wade Wilson received a healing factor that prevented his cancer from killing him.Marvel Source
Wade soon escaped the program and became a freelance mercenary using the name Deadpool, working for various criminal organizations. At times he has teamed up with heroes as well, but these attempts at "being a good guy" rarely stick for long.
Wade is mentally unstable, though whether this is a normal state or is caused by his constant state of hyper-regeneration is unknown. One side effect of his mental state is the belief that he is not a real person but actually a character in a comic book.
Bullets and blades and bombs, oh my!
For the Omega System look to Nanotechnology: SpinTech and to Special Weapons: Fury's Needle Gun. The reasoning behind SpinTech should be obvious, Fury's Needle gun may need a bit more explanation, for which I refer to Scourm's Build "The Harbinger of Death".For a better look at what I did Omega Build.
For Synergy I recommend (If you have them): Black Widow, Cable, Daredevil, Punisher, Rogue, Squirrel Girl, Thing, Thor, Venom, and Wolverine.
Gear I recommend:
Slot 1: Anti-Metal Ammunition
Slot 2: Beta Ray Wade Armor
Slot 3: Katanas of Gratuitous Violence
Slot 4: Luscious Loafers of Lasting 1337ness
Slot : Magic Satchel of Unlimited Weaponry
Insignia: Insignia of Bullseye
Legendary:
Gungnir
or
Savage Axe of Ares